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The anti-inflammatory and anxiolytic effects of caffeine were also demonstrated by a reduction in oxidative stress and lipid peroxidation [26, 28, 30, 31]

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Conclusions and Relevance Results of this case-control study reveal that the integration of normative modeling with semisupervised clustering provided both dimensional and categorical insights into ADHD heterogeneity, identifying 3 distinct ADHD biotypes with unique clinical-neural profiles that advance the understanding of ADHD’s neurobiological complexity and lay the groundwork for personalized management